Autosomal dominant mutations in ATP1A3 have been linked to rapid-onset dystonia parkinsonism (de Carvalho Aguiar et al, 2004; Bottger et al, 2011), alternating hemiplegia of childhood, and CAPOS syndrome, with more than 80 different disease-associated mutations reported, many of which target ion binding sites (Clausen et al, 2017). Here, ATP1A3 is linked to Rapid-onset dystonia-parkinsonism.