As with our experimental model, there was a greater proportion of M1 macrophages (CD68/HLADR or CD68/SOCS3 positive) in myocardial tissue from takotsubo cardiomyopathy patients when compared with control tissue, again reflecting a potential proinflammatory response (Figure 6). This evidence concerns the gene SOCS3 and Tako-tsubo cardiomyopathy.