AKT1 and pulmonary arterial hypertension: Because the inhibition of mTORC2 results in a paradoxical effect of experimental PH, we suggest that therapeutic regimens using inhibitors of the PI3K/AKT/mTOR signaling cascade for the treatment of PH and PAH should include an inhibitor of PDGFR (e.g., imatinib) due to the up-regulation of PDGFRα and PDGFRβ induced by mTORC2 inhibition.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Idiopathic PAH is a fatal and progressive disease characterized by increased PVR creating strain on the right ventricle that can progress to right heart failure and death.