The paradoxical effect of SM-specific KO of Rictor or inhibition of mTORC2 is also an important finding implying that combination use of inhibitors of mTORC2/AKT (and AKT/mTORC1) and inhibitors of PDGFRs would have a more efficient therapeutic or protective effect on PAH/PH. The gene discussed is AKT1; the disease is pulmonary arterial hypertension.