To examine the role of Raptor or mTORC1 in the development of experimental PH, we measured and compared the pulmonary hemodynamic variables (e.g., RVSP), right ventricular hypertrophy (RVH) (e.g., Fulton index) and pulmonary vascular remodeling (e.g., PA wall thickness) in RaptorSM−/− and WT mice before and after exposure to hypoxia for 3 weeks. This evidence concerns the gene RPTOR and Right ventricular hypertrophy.