Given that conventional CTE is caused by mutations in the EPCAM gene that encodes epithelial cell adhesion molecule (EpCAM)15, SPINT2 mutation-induced enteropathy may arise from enhanced EpCAM cleavage induced by dysregulated matriptase due to insufficient HAI-2 function, as suggested in a recent in vitro study by Wu et al.17. Here, EPCAM is linked to Abnormal intestine morphology.