Recent studies showed that patients that harbored a DN mutation in TP53 had earlier onset of a wide tumor spectrum than those with non-DN.10 We examined the IARC database of germline mutation carriers,11 and found a similar trend (age of onset for DN was 27.1 years old, n = 553; non-DN was 29.0 years old, n = 232; p = 0.13). The gene discussed is TP53; the disease is neoplasm.