In patients with type 2 diabetes and heart failure, 100 mg per day of (–)-epicatechin for 3 months increased peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), silent mating type information regulation 2 homolog (SIRT1), and mitochondrial transcription factor A (Tfam) (11). Here, TFAM is linked to heart failure.