Indeed, overexpression of PDK1 due to an increase in gene copy number or protein overexpression have been demonstrated in breast cancer and acute myeloid leukemia, among other malignancies [48] and can be of critical importance to boost the signal output of upstream alterations such as PTEN, PIK3CA and ERBB2 to Akt [49]. The gene discussed is ERBB2; the disease is breast carcinoma.