With respect to the type of epilepsy, significant decreases of 1.2-fold in SOD activity (p < 0.0001) and 1.1-fold in 8-OHdG levels (p = 0.0014) and significant increases of 1.1-fold in MDA levels (p = 0.0017) and 3-NT levels (p = 0.0226) in focal epilepsy were observed in comparison with those in generalized epilepsy. This evidence concerns the gene SOD1 and epilepsy.