Moderate increases in SOD activity and 8-OHdG levels in generalized epilepsy and CAT activity and 3-NT levels in idiopathic epilepsy were observed, indicating that the neurovascular unit and blood-brain barrier dysfunction increases OS and that the neuroinflammation present in epilepsy differs with brain regions, as has been observed in some clinical studies [56–59]. This evidence concerns the gene CAT and idiopathic generalized epilepsy.