Considering our results that apigenin alleviated apoptosis and autophagy, promoted cell proliferation in HBMVECs of OGD/R and improved neovascularization, ameliorated neurological function, and reduced cerebral infarction volume to play an important role in protecting brain tissue from ischemia/reperfusion injury via the Caveolin-1/VEGF pathway, apigenin may provide a promising treatment for the brain against ischemia/reperfusion injury. The gene discussed is CAV1; the disease is ischemia.