According to the “Orphan disease connections” portal (http://csbg.cnb.csic.es/odcs/disease_showresults.php?dis0=Melanoma%20and%20neural%20system%20tumor%20syndrome) [46], melanoma and Zellweger syndrome are considered connected diseases and PEX3 falls in the CDKN2A interactome, one of the most frequently mutated genes in melanoma. This evidence concerns the gene PEX3 and melanoma.