CDKN2A and Zellweger syndrome: According to the “Orphan disease connections” portal (http://csbg.cnb.csic.es/odcs/disease_showresults.php?dis0=Melanoma%20and%20neural%20system%20tumor%20syndrome) [46], melanoma and Zellweger syndrome are considered connected diseases and PEX3 falls in the CDKN2A interactome, one of the most frequently mutated genes in melanoma.