The analyses with NPH as basal insulin included 7, 18 and 14 studies (nocturnal hypoglycemia, total hypoglycemia and severe hypoglycemia, respectively), and those with long-acting insulin analogues included 1, 3 and 1 studies (nocturnal hypoglycemia, total hypoglycemia and severe hypoglycemia, respectively), and these analyses presented high heterogeneity, precluding their consideration as a definitive evidence of the possible superiority of NPH as compared to long-acting insulin analogues. The gene discussed is INS; the disease is Hypoglycemia.