Short-acting insulin analogues (aspart, glulisine, and lispro) were associated with a 32% lower risk rate of severe hypoglycemia when compared with regular human insulin (risk rate 0.68, 95% CI 0.60–0.77; 5945 patients, 15 studies; I2 = 0%) (Fig. 3). The gene discussed is INS; the disease is Hypoglycemia.