Researchers have also found that [3] SFI significantly decreased serum CK, LDH, and TNNI3 levels in myocardial ischemia/reperfusion injury (MIRI) rats, while it significantly increased the level of left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), maximal rate of the increase of left ventricular pressure (+dp/dtmax), maximal rate of the decrease of left ventricular pressure (-dp/dtmax), left ventricle ejection fraction percentage (EF), and stroke volume (SV). The gene discussed is TNNI3; the disease is myocardial ischemia.