TGF-β promotes transformation of fibroblast and ECM synthesis and inhibits ECM decomposition by regulation on matrix metalloproteinase, which not only leads to podocytes apoptosis, basement membrane denudation, and protein leakage, but also reduces nephrons (functional unit of kidney) and even glomerular sclerosis [16]. Here, TGFB1 is linked to Glomerular sclerosis.