ACTG1 and nodular sclerosis classical Hodgkin lymphoma: Another gene frequently mutated in our cohort of patients turned out to be ACTG1. Two out of the three mutations identified in this gene were detected as “de novo.” So far, several mutations in ACTG1 gene have been described and analyzed by protein modeling (van Wijk et al., 2003; Rendtorff et al., 2006) although de novo ACTG1 variants seem to be a rare cause of NSHL (Wang et al., 2018).