SIRT1, as a negative regulator, has been implicated in the modulation of PI3K/Akt pathway by deacetylation of the tumor suppressor PTEN (45) and down-regulation of both Akt and phosphorylation levels to inhibit the PI3K/Akt pathway in glioblastoma cells (46). This evidence concerns the gene AKT1 and glioblastoma.