CD274 and graft versus host disease: Consistently, in vivo blockade of PD-L1 signaling using anti-PD-L1 mAb (clone 10F.9G2) that blocks both PD-L1/CD80 and PD-L1/PD-1 interactions augmented GVHD and led to an increase in Glut1 expression and glycolysis with a subsequent reduction in mitochondrial respiration (OXPHOS) (64).