CXCR4 and Familial prostate cancer: Besides glioblastoma, SDF-1/CXCR4 signaling has been shown to be functional in stem(-like) subpopulations of retinoblastoma (60), melanoma (61), pancreatic ductal adenocarcinoma (62), non-small cell lung cancer (63), cervical carcinoma (64), prostate cancer (65), head and neck squamous cell carcinoma (66), rhabdomyosarcoma (67, 68), synovial sarcoma (56), and leukemia (69).