Besides glioblastoma, SDF-1/CXCR4 signaling has been shown to be functional in stem(-like) subpopulations of retinoblastoma (60), melanoma (61), pancreatic ductal adenocarcinoma (62), non-small cell lung cancer (63), cervical carcinoma (64), prostate cancer (65), head and neck squamous cell carcinoma (66), rhabdomyosarcoma (67, 68), synovial sarcoma (56), and leukemia (69). The gene discussed is CXCR4; the disease is melanoma.