BCL2L11 and Autoimmunity: This cluster sustains lymphocyte proliferation and inhibits cell death by targeting the tumor suppressor phosphatase and tensin homolog (PTEN) and the proapoptotic protein Bcl-2-like protein 11, commonly named Bim; indeed, lymphocyte-specific transgenic mice over-expressing the cluster die as a consequence of lymphoproliferative disease and autoimmunity (21, 22).