LAG3 and cancer: Lymphocyte activation gene-3 (LAG-3), T-cell immunoglobulin-3 (TIM-3), band T lymphocyte attenuator (BTLA) and T-cell immunoglobulin and ITIM domain (TIGIT) are highly expressed on exhausted T-cells and represent the next generation of immune checkpoints that are under evaluation for the treatment of chronic diseases including cancer and chronic viral infections such as HIV (Topalian et al., 2015; Chew et al., 2016; Dyck and Mills, 2017; Grabmeier-Pfistershammer et al., 2017; Manieri et al., 2017).