CD274 and cancer: In addition to targeting inhibitory receptors, blockade of the ligand PD-L1, by Atezolizumab, Durvalumab, and Avelumab, has demonstrated remarkable efficacy in lung, bladder, urothelial carcinoma and other cancers (Massard et al., 2016; Balar et al., 2017; Hsu et al., 2017; Rittmeyer et al., 2017).