The simultaneous blocking of the CTLA-4 and PD-1 pathways, given their distinct and non-overlapping mechanisms of action, has been the most successful combination tested thus far, resulting in tumor regression in patients with advanced melanoma, demonstrating the synergistic effects of combining checkpoint inhibitors (Wolchok et al., 2013; Hodi et al., 2016; Weber et al., 2016). Here, CTLA4 is linked to melanoma.