IL10 and gastroenteritis: In conclusion, we succeeded in the construction of a new Bifidobacteria Expression SysTem (BEST) that allowed in vivo IL-10 delivery by B. bifidum. Furthermore, the use of recombinant B. bifidum BS42 secreting IL-10 cytokine in a model of low-grade intestinal inflammation showed its ability to decrease local inflammation and confirmed therefore its potential for delivery of therapeutic molecules in the colon.