Clinical trials conducted by the National Institute on Alcohol Abuse and Alcoholism at NIH, Bethesda, MD, United States, have shown that the use of CRFR1 antagonists does not provide therapeutic effects in individuals suffering from alcohol dependence (Shaham and de Wit, 2016; Spierling and Zorrilla, 2017). The gene discussed is CRHR1; the disease is alcohol dependence.