Among of them, prothrombin (F2, Uniprot ID: P00734), mitogen-activated protein kinase 10 (MAPK10, Uniprot ID: P53779), estrogen receptor (ESR1, Uniprot ID: P03372), caspase-3 (CASP3, Uniprot ID: P42574), chymase (CMA1, Uniprot ID: P23946), amine oxidase B (MAOB, Uniprot ID: P27338), and superoxide dismutase 2 (SOD2, Uniprot ID: P04179) were closely relative to MI issues inferring to myocardial infarction, coronary ischemic syndrome, coronary heart disease, angina, ischemia, heart failure, or oxidative injury. This evidence concerns the gene ESR1 and coronary artery disorder.