Among of them, prothrombin (F2, Uniprot ID: P00734), mitogen-activated protein kinase 10 (MAPK10, Uniprot ID: P53779), estrogen receptor (ESR1, Uniprot ID: P03372), caspase-3 (CASP3, Uniprot ID: P42574), chymase (CMA1, Uniprot ID: P23946), amine oxidase B (MAOB, Uniprot ID: P27338), and superoxide dismutase 2 (SOD2, Uniprot ID: P04179) were closely relative to MI issues inferring to myocardial infarction, coronary ischemic syndrome, coronary heart disease, angina, ischemia, heart failure, or oxidative injury. The gene discussed is CASP3; the disease is myocardial infarction.