The results displayed that 2ME2 markedly suppressed the expression of HIF-1α and IRAK-M at 1 h after brain ischemia compared with the vehicle treated group (Figures 1C,D), indicating that the increase of HIF-1α correlates with the upregulation of IRAK-M after cerebrovascular obstruction and reperfusion. Here, IRAK3 is linked to brain ischemia.