These include using aSyn lentivirus in mice, brains from familial PD and Dementia with Lewy Bodies (DLB) subjects, cell free assays, and aSyn transgenic mice where we confirmed that TH and PP2A activities become dysregulated when aSyn aggregates (Alerte et al., 2008; Wu et al., 2012; Farrell et al., 2014). The gene discussed is TH; the disease is Lewy body dementia.