HOXB8 and colorectal carcinoma: While successfully constructed the overexpression of HOXB8 in DLD1 cell (Fig. 2a), we performed MTT and colony formation assays to evaluate the effects of HOXB8 on the proliferation of CRC cells, and we also evaluate the effect of HOXB8 on the migration and invasion of CRC cells by performing wound healing and transwell assays.