Based on the finding that TERT-specific CTLs have been identified in the blood of B-CLL patients and TCRs with high avidity for human TERT could be isolated from TERT-vaccinated transgenic mice, adoptive HLA-A2-TERT-TCR-T cells could control B-CLL progression without severe side-effects in humanized mice. This evidence concerns the gene TERT and B-cell chronic lymphocytic leukemia.