HLA-DPB1*05:01-WT1332-TCR-modified-CD4+ T cells displayed a strong proliferative response and Th1-type cytokine production in response to WT1332 peptide, WT1 protein, or WT1-expressing tumor cell lysate and lysed HLA-DPB1*05:01+ WT1+ human leukemia cells via the granzyme B/perforin pathway. Here, WT1 is linked to neoplasm.