In this regard, in a PD model involving overexpression of an aggregation-prone α-synuclein and of TPPP/p25a, a microtubule-binding protein involved in α-synuclein-aggregate formation, α-synuclein was localized to autophagosomes since it colocalized with autophagy markers LC3 and p62/SQSTM1, but these autophagosomes did not fuse with lysosomes. Here, SQSTM1 is linked to Parkinson disease.