However, despite significant IFN-γ reduction in cardiac tissue, TNF-α expression was similar between WT and IL-4−/−, both in uninfected mice (NI WT vs. NI IL-4−/−, p > 0.17) and after infection (Inf WT vs. Inf IL-4−/−, p > 0.5). The gene discussed is IFNG; the disease is infection.