A similar augmentation in disease was observed when Thbs3 DTG animals were subjected to myocardial infarction (MI) injury over 4 weeks, showing increased heart size (Fig. 2g, h) and a greater loss in ventricular performance with enhanced ventricular dilation compared with tTA controls (Fig. 2i, j). The gene discussed is THBS3; the disease is myocardial infarction.