THBS1 and heart disorder: Moreover, Thbs1/2/4/5−/− mice that only express endogenous Thbs3 with injury showed the same membrane stability defect with greater pathology and premature lethality following cardiac disease stimuli, which was also associated with reduced integrins at the sarcolemma because Thbs1/2/3/4/5−/− mice showed a near complete rescue of these effects.