Indeed, the selective killing of tumor cells carrying mutations in BRCA1 or BRCA2 by olaparib has led to the clinical registrations of PARP inhibitors in such settings, and there is hope that this potential will be extended to tumors with mutations in other genes, such as ATM, that are thought to share molecular features with BRCA-mutant cells16. This evidence concerns the gene PARP1 and neoplasm.