We also observed fewer dCTLA-4+Tim-3+CD4+T cells and higher expression of Th1-type cytokines, but lower Th2-type and Treg-type cytokines by dCTLA-4+Tim-3+CD4+T cells in female CBA/J mated with male DBA/2 mice, a well-established model of abortion (Fig. 7). Here, CD4 is linked to abortion.