Specifically, we observed that low expression of a signature comprising the top 5 downregulated genes (DECR1, GFM2, DOCK9, VDAC3 and ETFB) (P < 0.0005) associates with increased overall survival in patients from a compendium of breast cancer studies (N = 626) included in the KMplot database (Fig. 6d)35. This evidence concerns the gene VDAC3 and breast cancer.