For example, Thymic Epithelial Tumors show downregulated miR-145-5p and increased expression of its motility-related target genes Golm-1, EGFR and CDH2; moreover, in breast cancer miR-145 exogenous expression was shown to promote the inhibition of cell growth and the induction of apoptosis by targeting the Rho-effector rhotekin (RTKN)18,21. This evidence concerns the gene RTKN and breast carcinoma.