As shown in Fig. 6f, upper panel, quantified in Fig. 6g, upper panel, mice with MSCV and HA-HACE1-C876S-expressing HOS tumors showed marked tumor replacement in spleens from 3/3 tumor-bearing mice, while we failed to detect any tumor spread to splenic tissues of mice bearing HA-HACE1-expressing tumors. This evidence concerns the gene HACE1 and neoplasm.