To determine if faster disease progression can be differentiated from slower disease progression by CD4+ T-cell decline and level in cases of HIV-2 infection also, as had been previously suggested for HIV-1 infection (12, 14), we analyzed the time to the appearance of AIDS from the first recorded percentages of CD4 (CD4%) for all HIV-2-infected individuals in the cohort with two or more CD4% measurements (n = 192). Here, CD4 is linked to HIV-1 infection.