While WT C. albicans induced both maturation and secretion of IL-1β in unprimed macrophages, both of these inflammasome responses were diminished upon infection with the ece1Δ/Δ strain, demonstrating that an ECE1-derived fungal factor was crucial for C. albicans-induced Nlrp3 inflammasome activation (Fig. 2E and F). This evidence concerns the gene IL1B and infection.