Aligned with the recently identified role of APOC3 in insulin resistance, HOMA-IR, plasma insulin levels, body weight, and adiposity correlated positively with HDL-associated APOC3 levels (r = 0.50, P = 0.00017; r = 0.44, P = 0.0015; r = 0.23, P = 0.048; r = 0.26, P = 0.021, respectively). The gene discussed is APOC3; the disease is Insulin resistance.