SOD1 and amyotrophic lateral sclerosis: Mice expressing WT-SOD1 fused to yellow fluorescent protein (SOD1:YFP) do not develop ALS-like paralysis and do not show evidence of WT-SOD1:YFP aggregation at advanced ages; whereas equivalently expressed fALS mutant G85R-SOD1:YFP produces paralysis with obvious inclusion pathology (Wang et al. 2009).