In addition, isoforms E2 and E4 have been shown to promote atherosclerosis via Reelin by increasing vascular inflammation (Ding et al. 2016), thereby increasing the risk for cerebrovascular and cardiovascular pathologies (Lopez et al. 2014) as well as neurological pathologies, specifically Alzheimer’s disease (Weiner et al. 2014). This evidence concerns the gene RELN and early-onset autosomal dominant Alzheimer disease.