Immune-checkpoint blockade (ICB) involving the use of monoclonal antibodies to modulate the immune checkpoints such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) is the other rapidly evolving approach that has demonstrated strong potency and durable efficacy in the frontline treatment of advanced melanomas including B-RAF mutated melanomas [1, 3]. The gene discussed is BRAF; the disease is melanoma.