The interaction between annexin A2, S100A10 and tissue plasminogen activator (t-PA) mediates the conversion of plasminogen to plasmin which facilitates the extracellular matrix (ECM) degradation, matrix metalloproteinase (MMP) activation, epithelial to mesenchymal transition (EMT) and angiogenesis, leading to increased cancer cell migration and invasion [8, 15, 16]. This evidence concerns the gene PLAT and cancer.