A recent retrospective analysis on a cohort of 509 patients with primary, non-metastatic breast cancer (median follow-up: 8.50 years; median age of participants: 60 years) found that RANKL serum levels were significantly higher in patients with disseminated tumor cells in the bone marrow, as well as in patients who developed bone metastases. The gene discussed is TNFSF11; the disease is neoplasm.