A recent retrospective analysis on a cohort of 509 patients with primary, non-metastatic breast cancer (median follow-up: 8.50 years; median age of participants: 60 years) found that RANKL serum levels were significantly higher in patients with disseminated tumor cells in the bone marrow, as well as in patients who developed bone metastases. This evidence concerns the gene TNFSF11 and breast carcinoma.