Our findings provides not only novel mechanisms for the study of glioma angiogenesis, but also new potential targets for anti-angiogenesis therapies of glioma in the view of multiple molecular control network of MOV10 (RNA binding protein), circ-DICER1 (circRNAs), miR-103a-3p/miR-382-5p (miRNAs), ZIC4 (transcription factor), and Hsp90 β (target gene). The gene discussed is ZIC4; the disease is glioma.