TNF and myocardial infarction: Myocardial infarction is a condition characterized by the cardiac muscle necrosis, due to cell death caused by inflammation, which may be initiated by oxidative stress that produces cytokines synthesis, such as tumor necrosis factor-α (TNF-α) and interleukins (IL-1β and − 6); reabsorption of necrotic tissue; exacerbated collagen deposition; and hypertrophy.