ERBB2 and osteosarcoma: As expected, the RIP and luciferase reporter assays validated that TINCR regulated HER-2 expression by sponging miR-125b, which is widely studied and verified as a potential tumor suppressor gene in glioma [40], bladder cancer [41], breast cancer [42], osteosarcoma [43], hepatocellular carcinoma [44], and melanoma [45].