ESR1 and neoplasm: SCC (vs. IDC) was associated with poorer OS in univariate analysis (HR = 2.39, 95%CI 2.06–2.77, P < 0.001), and in multivariate (HR = 1.40,95%CI 1.17–1.67, P < 0.001) analysis after adjusting for age, race, comorbidity, T-stage, N-stage, M-stage, ER, PR, tumor grade, LVI, surgery, endocrine therapy, chemotherapy and RT (Table 3, & Additional file 1: Figure S1).