The incidence rate of stroke was 14.64/1000 person – year (95% CI 10.74–19.97) (IRR 2.13 when Type 2 DM (+) group under human or analogous insulin treatment was compared with Type 2 DM (+) group without treatment with human or analogous insulin, 95% IC 1.60–2.80). The gene discussed is INS; the disease is Stroke.