The remaining 13 genes showed a general down-regulation in the susceptible tissue samples, i.e., of mice and tumor-bearing Spalax. We found known cancer-related genes such as Ntrk1, Serpina6, Nme3, and Sstr4. We also found significant differences in the level of expression of mitochondrial uncoupling protein (UCP1) in tumor-resistant samples (Spalax control and Spalax UIS cancer negative) in comparison with the cancer-sensitive group (mouse control, mouse UIS, and Spalax UIS cancer positive). The gene discussed is NME3; the disease is cancer.