POSTN and melanoma: Kaplan-Meier analysis revealed that patients with high expression of periostin had significantly shorter disease-free survival (DFS) and melanoma-specific survival (MSS) (DFS: hazard ratio (HR) 2.832, 95% confidence interval (CI) 1.267–6.329, p = 0.011; MSS: HR 2.980, 95% CI 1.148–7.741, p = 0.013) (Figure 4C).