This results in permanent AKT1 kinase activity and phosphorylation at Thr-308 and Ser-473, as well as the consequent activation of downstream target proteins independent of growth factor stimulation, as reported in different cancers such as breast cancer, endometrial cancer, bladder cancer, lung cancer, and colorectal cancer [150,151,152,153]. Here, AKT1 is linked to urinary bladder cancer.