KANK1 and bilirubin encephalopathy: However, for the other gene, KANK1, there may be a stronger relationship, given that deletions in this gene have been associated with cerebral palsy and alterations in neurodevelopment [74] and it is known that, in the case of extreme hyperbilirubinemia in the newborn neurological sequelae can occur, including the Kernicterus Spectrum Disorders [30,75].